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Multiple a-list entertainers are scheduled to perform at the Obama Presidential Center's grand opening ceremony on Thursday.

A fast-moving fire in Madison, Ill., on Tuesday morning destroyed one home and significantly damaged neighboring residences. 10-year-old Eder Escobar Vasquez alerted his neighbor, David Wood, to the blaze which authorities say originated in a vacant, condemned home around 9 a.m.

The campaign is heating up for a proposed constitutional amendment that would make it harder to amend the state constitution itself.

A 46-year-old murder mystery in West County will now be featured on a deck of playing cards going into Missouri prisons.

United States Immigration and Customs Enforcement has deported a woman who allegedly tried to give up her baby at a Lake St. Louis hospital due to debt she accrued coming to the country illegally.

A former Senior Airman stationed at Scott Air Force Base has been sentenced to federal prison after he admitted to sexually exploiting minors and distributing images and videos of child sexual abuse material.

Severe storms are likely to roll through the St. Louis region on Wednesday evening, bringing the potential for gusty winds, hail and possibly even tornadoes.

Kids at Shriners Children’s Hospital in St. Louis are getting a colorful, hands-on role in a major national art project tied to America’s 250th anniversary.

A man was arrested Monday evening for allegedly touching children in the pool at the Shaw Park Aquatic Center in Clayton.

The names of the 11 skydivers and pilot killed in the Butler, Missouri plane crash June 14 have been released by Bates County.

For 65 years, the BackStoppers has supported the families of fallen and injured officers. Now, the BackStoppers is launching a cardiac wellness program, its first preventative initiative ever.

One person was fatally shot Tuesday morning in East St. Louis, according to Illinois State Police.

A man has been sentenced to life in prison for a targeted murder in north St. Louis that was captured on Facebook Live in 2024.

Anheuser-Busch recently announced a $20 million investment into its St. Louis brewery and its Arnold, Missouri, canning plant.

A Sparta, Illinois, man charged in a deadly animal abuse case is due in court Tuesday.

The Denver Broncos have signed St. Louis Battlehawks' standouts Hakeem Butler and Sean Fresch Jr. ahead of the start of the team's upcoming minicamp.

Centene, one of the St. Louis region's largest healthcare companies, will offer voluntary buyouts to a number of employees, though the company has not confirmed how many workers could be affected.

ST. LOUIS - St. Louis City Police are searching for a missing 65-year-old. According to the St. Louis Metropolitan Police Department, Carolyn Adams, 65, was reported missing on June 5. She was last seen wearing a gray hooded sweatshirt, white T-shirt and white tennis shoes. If anyone has information on Adams' whereabouts, contact the department's [...]

A new set of Illinois laws is set to take effect July 1, ushering in changes that will affect everything from how people get around town to how schools handle bullying and how older drivers renew their licenses.

A mother has been jailed after her two young children were found severely emaciated earlier this week. One of the children died after being underfed.