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The O'Fallon Police Department is seeking public assistance to locate Jacob Martin, a nonverbal 12-year-old with autism who went missing near Veterans Memorial Parkway and Sonderen Street.

A new Missouri law taking effect Thursday will prohibit stores without a marijuana license from selling consumable hemp products containing THC, leaving some business owners and customers worried about losing access to products they say have helped them for years.

Sen. Josh Hawley (R-Mo.) introduced four amendments to a Senate Transmission Bill aimed at protecting farmers from eminent domain in major electric transmission projects.

One man was shot dead Tuesday afternoon in Spanish Lake. Authorities have a person of interest in custody.

Families will have the chance to travel through millions of years of Earth's history when Jurassic Quest returns to the St. Charles Convention Center from Nov. 20-22.

The U.S. House of Representatives passed a bill sponsored by U.S Representative Mike Bost, Illinois 12th Congressional District, to expand healthcare and mental health access for Veterans.

The survivor of a sexual assault that sent a St. Louis ride-booking driver to prison is speaking out.

Interstate 64 was shut down in both directions for more than two hours Wednesday afternoon and evening after power line fell on the interstate at Clarkson Road/Olive Boulevard in Chesterfield.

Veterans Day Wednesday marked the annual remembrance at Soldiers Memorial that paid respect to Missourians that served in the U.S. Armed Forces.

The Cheesecake Factory has opened a new restaurant at West County Center shopping mall.

As Route 66 turns 100, travelers from across the globe are hitting the road to experience a piece of Americana.

Some anniversaries are marked with speeches, flowers and candles. The St. Louis Black Repertory Company is celebrating its 50th anniversary the way it knows best: with powerhouse vocals, legendary music and an evening guaranteed to have audiences singing along and dancing in their seats.

The Red Cross says blood donations often decline during the busy holiday months as schedules fill up with seasonal events and travel. Officials are especially urging people with type O blood to make an appointment to donate.

Kennelwood Pet Resorts issued guidance on recognizing canine respiratory illness symptoms, such as coughing and lethargy, to help owners protect their pets during cold weather.

FOX 2's Margie Ellisor honors her late grandfather, Cpl. Cameron Gray, who earned a Silver Star for rescuing wounded soldiers under fire in France during World War II.

Providing property tax relief for disabled veterans will once again be up for debate when lawmakers convene for the new legislative session in January.

Gateway Regional Medical Center remains on diversion status, forcing Granite City ambulances to seek alternative destinations due to ongoing emergency room limitations.

The St. Louis Fire Department says the site of Wednesday morning’s fatal house fire had no electricity, and that residents were using candles to keep warm.

The St. Louis-based Donald Danforth Plant Science Center partnered with Rwanda's Food Innovation Partnership to advance agricultural technology and food security.

After major repairs, a century-old Statue of Liberty replica is standing tall once again in Sauget, Illinois.