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O'Neill becomes first Cardinal hitter since 1928 with five RBIs on opening day, while Wainwright pitches six scoreless for 100th win at Busch III.

While many U.S. states and schools have since stopped requiring mask-wearing for COVID, disease experts say children will still need high-quality masks for everything from current and future pandemics to seasonal flu and respiratory syncytial virus that can cause serious…

Neidorff, who died Thursday, led the Clayton-based health insurance company for 26 years, growing it into a behemoth in the managed care industry.

The St. Louis police chief said the department reviewed video tapes and found no evidence two officers committed a crime or were intentionally misleading.

The family of Katlyn Alix, a St. Louis police officer fatally shot by a fellow officer in 2019, settled a lawsuit this week with another former colleague.

The former first lady’s recent statements raise questions about whether officials missed a chance to intervene before the former governor’s alleged abuse.

After two COVID-impacted seasons openers — one canceled, one abbreviated — throngs of fans show up Thursday at Busch Stadium for the area’s unofficial holiday.

SPRINGFIELD, Ill. — Gov. J.B. Pritzker and leaders of the Illinois House and Senate on Thursday announced agreement on a state spending plan that aims to fight nagging, near-record inflation by giving $1.8 billion back to taxpayers.

Terms of the new agreement were not disclosed, but Bayer said it is "continuing work to settle the Roundup litigation on reasonable terms."

Messenger: Video obtained by St. Louis circuit attorney’s office contradicts police version.

Leron Harris stood trial in St. Louis in the Nov. 1, 2019, shooting death of Mark Schlemmer.

Police on Wednesday arrested a woman who they believe fatally shot another woman in the 1200 block of Kroeger Avenue in Dellwood.

A video released Thursday shows a trooper pleading for a Madison County man to drop his weapon before that man is shot by police near the town of Pana.

More money would flow to charters from the state, not from St. Louis Public Schools.

Lisa M. Matlock won as a write-in candidate.

Every player in opening-day lineup hit double-figure home runs last season. Wainwright is 21-7 against Pirates and has 99 career wins at Busch.

The Missouri House signed off on a $46 billion spending plan Thursday.

Maryville University, nationally renowned for its two esports teams, is hoping to attract more students to the Town and Country college.

County Executive Steve Ehlmann has asked the County Council to name a new 199-acre park near Wentzville after Benjamin Oglesby, a former slave who owned some of the old farm property for 30 years.

Boeing's CEO made 169 times a median employee’s $124,844 salary in 2021, the company said.