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Only one in 10,000 active ingredients created by researchers in a lab is turned into a potential drug. But pharmaceutical research is not only expensive and time-consuming, it’s also a process liable to lead to a dead end. How do drugs make the long journey from lab to market? Even today, only a handful of vaccines against the coronavirus have been developed and made available to people in many countries around the globe, so the threat of Covid-19 remains. There is still no effective treatment…

The deal involves a firm with more than 500 real estate agents and $1.3 billion in 2021 sales volume.

The Supreme Court's ruling Thursday related only to the federal agency's vaccine mandate-or-testing rule, and it doesn't prohibit companies enacting mandates of their own. A pair of St. Louis lawyers explain why that makes for a challenging landscape for companies operating in multiple states.

Another one bites the dust – at least, temporarily. Fuzzy’s Taco Shop announced in an email to customers Thursday it is closing its four St. Louis-area locations and Columbia, Missouri, restaurant “for the time being.” “We love our Fuzzy’s fans and the good vibes you bring us. We look forward to seeing your faces again soon,” the email stated. “It’s not a goodbye, it’s a see you later.” Fuzzy’s did not give a reason for the temporary closure. The restaurant chain's St.…

A development executive returns to the St. Louis Symphony Orchestra as its new vice president and chief philanthropy officer after holding several roles at another local nonprofit.

The St. Louis Business Journal has extended the nomination deadline for its 2022 Commercial Real Estate Awards program (formerly the Building St. Louis Awards), which seek to honor real estate projects that have created a positive impact in the region.

St. Louis Community College has released “Education for Life,” its annual report for the 2019-2020 academic year. Covering topics from its response to the COVID-19 pandemic; student, faculty, staff and campus achievement; and workforce development programs, the annual report highlights activity at the college in a number of areas. The report also includes information on college demographics, the Opportunity for All campaign and its financial fitness. Visit the college’s website to learn…

City Winery, with locations in Atlanta, Boston, Hudson Valley, New York, Nashville, New York City, Philadelphia, and Washington D.C., will offer intimate concerts and live performances, food and wine experiences, private event spaces, upscale dining options, and a fully functioning winery, officials said.

SSM Health named Jake Brooks president of its St. Joseph Hospitals in St. Charles and Wentzville, effective Jan. 16.

Sometimes the correct conclusion that a picture is worth a thousand words is an understatement.

St. Louis startups reeled in the cash in 2021. Local startups raised $699 million in venture financing in 2021, according to a report published Friday by research firm PitchBook and the National Venture Capital Association. That’s up from the $490 million local startups snagged in 2020. The bulk of the 2021 funding came in the year’s second half, which included nearly $600 million in financing for St. Louis firms. The 2021 total marks the most venture funding St. Louis firms have raised in…

Covid-19 is causing cancellations and closings as officials try to get the surge of cases under control. Some local restaurants have decided to temporarily shut down during this time, as have several St. Louis-area attractions. The latest to do so is the Saint Louis Science Center. In a news release Thursday, science center officials wrote, "Due to the surge of the Omicron variant of Covid-19 within the St. Louis community, the Saint Louis Science Center announced it will temporarily close for…

The AT&T tower, downtown’s largest office building, is once again under contract, following an appraisal that showed the building’s value has dropped by more than 95% since it sold for more than $200 million in 2006.

An academic said helping a local museum commemorate the protests "helps our community – including young residents, immigrant communities, and other newcomers – take stock of what has been sought, truly achieved, and remains unrealized as struggles for economic and social justice continue."

Steve Mackin, who will take the helm of St. Louis-based multistate health system Mercy this spring, has announced his senior leadership team.

Emily Lohse-Busch, who has led the nonprofit startup funder for nearly half its existence, will step down from her role next month. However, she plans to remain in the region and engaged in its economic development efforts.

Richard Schneider never expected to become an entrepreneur. However, a project that stemmed from his home theater business turned him into a business owner.

Logan University has turned to a St. Louis Cardinals team physician to take on a key post within its new master's in athletic training program.

St. Louis has the largest Bosnian population in the United States. Now leaders want to do the same thing with Afghan refugees. "Anyone from any corner of the earth can come to America and become an American," Mojda Sidiqi said, referencing a photo of herself at 9 years old. Born in Kabul, Sidiqi outlined her own experience immigrating from Afghanistan, as stakeholders — led by Arch Grants founder Jerry Schlichter — unveiled a new plan Wednesday to market St. Louis to current Afghan refugees…

Nine PBS, the nonprofit St. Louis-area affiliate of the Public Broadcasting Service, has named a new vice president and chief content officer, a role previously held by Amy Shaw, who is currently president and CEO of Nine PBS.