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Governor J.B. Pritzker declared the monkeypox virus outbreak a public health emergency Monday.  

A CIA drone strike has killed al-Qaida leader Ayman al-Zawahri in Afghanistan, according to five people familiar with the matter.

Police responded to a man getting shot in the head inside a lobby of a Greyhound station Monday.

The new 557 area code will be given to customers in the 314 region who request new service or additional phone lines.

Anheuser-Busch is delivering more than 50,000 cans of emergency drinking water as a request from the American Red Cross to the St. Louis region.

Finland and Sweden in May announced their intentions to join NATO following Russia's attack on Ukraine.

EUREKA, Mo. - A Eureka, Missouri home built on a bluff overlooking the Meramec River is coming to market on Saturday at $1.89 million. The four-level home, located on a 3-acre lot, is in the Rockwood School District. It has three bedrooms and six bathrooms. The 5,115-square-foot home is complete with unique features like the [...]

Former President Donald Trump endorsed three incumbents in Missouri Congressional races ahead of Tuesday’s primary election.

A woman was shot in the chest outside of a Walgreens in the Jeff-Vander-Lou neighborhood Monday.

We looked at several sample ballots in the St. Louis region to give you an idea of what people will decide on Tuesday.

Police have identified a man who drowned in his car during last week's historic rainfall and flash flooding across St. Louis.

ST. LOUIS – A St. Louis man admitted he was involved in a fatal 2019 carjacking and is now facing at least 23 years in federal prison. Jalen Exavier Simms, 27, was supposed to stand trial Monday in front of U.S. District Court Judge Henry E. Autrey for one count of attempted carjacking resulting in [...]

ST. CHARLES COUNTY, Mo. - Only one westbound I-70 lane will be open on Thursday night into Friday morning in St. Charles County while work is being done. Crews will repair the interstate pavement between RouteZ/Church Street and Wentzville Parkway from Thursday at 8 p.m. to Friday at 6 a.m. The right lane of I-70 will [...]

Tis the season for excessive social media scrolling, baseball fans. The clock is winding down on the MLB trade deadline.

ST. LOUIS - A heat advisory will be in effect in the St. Louis area this week. The heat advisory will be in effect from 1 p.m. Monday to 8 p.m. Wednesday. Heat index values are expected to be around 105 daily. These temperatures will impact parts of south-central and southwest Illinois as well as [...]

ST. LOUIS COUNTY, Mo. - An endangered silver advisory has been issued for a 74-year-old man. The Missouri State Highway Patrol said Craig Scott Dedoyard went missing on Friday at 4:30 p.m. from the 11000 block of Marley Drive in south St. Louis County. He has been diagnosed with early Alzheimer's disease, dementia, and memory [...]

Attention this week turns back to three consecutive days of heat and humidity.

The American Red Cross is also helping flood victims with shelter and supplies.

A 15-year-old girl was shot in north St. Louis early Monday morning.

Police were on the scene of a shooting that left a man dead in St. Louis city early Monday morning.