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One woman was killed and three other people were hurt after a wrong-way crash late Friday evening in north St. Louis County.

A Missouri bill that would permit FDA-approved clinical trials for psychedelic therapies is moving to the state Senate. The legislation aims to provide new treatment options for veterans and first responders.

The Hyatt Regency at the Arch is hosting the Predator Pro Billiard Series this weekend. Some of the nation's top pool players are in St. Louis, competing for prizes and showcasing the sport's growing popularity.

A youth teen violence prevention town hall event Saturday in north St. Louis County brought together leaders and families to talk about what can be done to prevent youth violence.

UConn advances to its third national title game in four seasons, beating Illinois 71-62 in the NCAA March Madness Final Four.

This Easter, the Humane Society of Missouri is reminding everyone of the commitment and responsibility that comes with adopting a rabbit.

"I have to keep remembering just the experience itself. It was such a great experience."

With long-term contract extensions for MLB prospects and rookies becoming more common, it's natural to wonder whether the St. Louis Cardinals could follow suit with JJ Wetherholt.

Kerry Carpenter, Zach McKinstry and Matt Vierling hit two-run homers and drove in three runs apiece, and the Detroit Tigers powered their way to an 11-6, rain-shortened victory over the St. Louis Cardinals on Saturday.

The Missouri House has approved a bill designed to fast-track redevelopment in downtown St. Louis by offering major tax incentives for turning vacant office buildings into new homes and businesses.

A man from Fairview Heights, Illinois, was sentenced Friday in a 2023 sexual assault case at Gateway Arch National Park.

Three people have died and at least six others are injured after multiple shootings in the City of St. Louis since Friday, according to the St. Louis Metropolitan Police Department.

The Kirkwood Police Department and FBI agents are responding to reports of a suspicious package Saturday afternoon at a local post office.

Illinois (No. 3 seed) will take on UConn (No. 2 seed) in the first of two Final Four matchups on Saturday.

TEL AVIV, Israel (AP) — U.S. President Donald Trump warned Iran to open the crucial Strait of Hormuz by his Monday deadline and Tehran called his threat “unbalanced and foolish." The search for a missing U.S. military pilot continued Saturday in a remote part of the Islamic Republic. Trump has called Tehran “beaten and completely decimated " in the war, now in its sixth [...]

ST. LOUIS - St. Louis police officers are investigating two overnight shootings that happened within a span of just 90 minutes. Around 1 a.m. police say a man was shot and killed on South Broadway in the Mount Pleasant neighborhood. About six miles north of that first scene another man was shot on Locust Street [...]

Grammy Award-nominated rapper Sexyy Red launched her new nonprofit organization, "Giving is Sexyy," during an Easter giveaway event Friday in Pagedale. The St. Louis native hosted the celebration at Prince Beauty Supply to provide resources and support to local families.

Precious Jones knows heartache all too well.  She lost her brother, Paul Jones, in 2021. Her son Preston Jones was 20 years old when he was shot and killed the next year.

Crews began demolishing the tornado-damaged Urban League Plaza in north St. Louis on Wednesday, nearly one year after a devastating storm moved through the area. The start of the demolition comes as city officials approved $11 million in new recovery funding.

St. Louis residents visited local confectioneries and candy shops on Good Friday to continue long-standing holiday traditions. Businesses across the city reported high customer volume as families gathered to purchase chocolate rabbits and other Easter sweets.