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Rafael Flores Jr. hit a three-run home run and Brandon Lowe added a solo shot to lift the Pittsburgh Pirates to a 6-2 victory over the St. Louis Cardinals on Saturday.

One man was shot Saturday afternoon in north St. Louis County after an apparent dispute between two family members, police say.

The Lawrence County Sheriff's Office is investigating the death of a juvenile as a potential homicide following the discovery of a body at a rural residence in Lawrence County, Missouri.

Todd Thomas, the St. Louis Cardinals' in-game emcee who famously implores fans to "make some noise," says he is stepping back from his regular gameday duties after 30 seasons.

A St. Clair County tax preparer who admitted to filing hundreds of false tax returns, lying about her personal income, and falsifying her clients' business expenses has been sentenced to federal prison.

An investigation is underway after a woman was fatally shot Saturday in south St. Louis.

Dozens of new Missouri laws took effect on Friday. Among them, a law that strengthens penalties for drivers who pass stopped school buses.

After losing her husband to pancreatic cancer in 2023, Kira Andersen has turned her family’s heartbreak into a mission to give other cancer patients more options, raising $2.85 million toward a $3 million goal to help advance cancer research.

ST. LOUIS - It'll heat up through the weekend and into next week, with some of the hottest temperatures we’ve seen so far this year. However, humidity will remain lower than during our previous “heat waves,” so heat index values won’t get too high. We can expect highs near or just shy of 90 on [...]

Two kittens are recovering after police say they were thrown from a moving truck inside a duffel bag and covered in what appeared to be bleach.

Pastor Robert Strong estimates the cost to replace two air conditioning units destroyed on the roof of his church to be more than $75,000. Kossuth Church of God in Christ is on Clarence Avenue in North St. Louis.

A bizarre situation was caught on camera earlier this week. A south St. Louis man says he was saying "bye" to his kids before work. That's when he says a stranger started going through his car, right in front of them.

Quinn Mathews allowed one run over 5 2/3 innings for his first major league win and Jimmy Crooks hit a two-run homer to lead the St. Louis Cardinals to a 4-1 victory over the Pittsburgh Pirates on Friday night.

The St. Louis Board of Aldermen advanced a board bill Friday to impose new regulations for data centers.

A judge did not make a decision as expected Friday on whether to hold a special election to replace the Mayor of Festus and three city council members.

Dolly Parton’s legacy is being remembered in a special way at a café in Bourbon, Missouri, where the owner said the country music icon has been part of her life since childhood.

Dozens of new laws take effect in Missouri on Friday, including one restoring voting rights to more than 41,000 Missourians on felony probation or parole.

A man accused in a deadly shooting shortly after a car crash Thursday in St. Louis' Wells-Goodfellow neighborhood is now behind bars on criminal charges.

After a fatal dog attack on Thursday night, people living in a Washington Park neighborhood say they have dealt with a pack of wandering dogs for years and feared something like this would eventually happen.

This month marks three years since a group of six people vanished without a trace from Berkeley, Missouri. Two of them are children. Now, police investigators and family members hope renewed attention to the case will bring answers.