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A Kirkwood woman and an oncologist emphasized the importance of pursuing clinical trials early to improve both survival rates and quality of life for patients with small cell lung cancer.

The owners and staff at Petland in Fenton Crossing are celebrating the safe return of a puppy that was stolen from the store nearly seven months ago.

QUINCY, Ill. — Nearly a month after winning a historic $1.04 billion Powerball jackpot, the lucky Illinois lottery player who snagged the prize has finally come forward to claim their winnings. According to officials from the Illinois Lottery, the big winner, who chose to stay anonymous, snagged the $1.04 billion jackpot prize during the Wednesday, [...]

LYONS TOWSHIP, Ill. (WGN) — A soap opera-style drama in the suburbs is renewing questions about the relevance of one level of local government — townships. According to available public records, townships cost Illinois taxpayers about three-quarters of $1 billion a year, but our questions start with a single kiss. A kiss caught on camera, [...]

A proposal to increase the speed limit on Interstate 44 from 70 to 75 miles per hour has sparked debate among drivers regarding highway safety and traffic flow.

Forbes has released its annual "Forbes 400" List, ranking the 400 wealthiest Americans in 2026. This year's list includes five individuals with deep ties to St. Louis.

ST. LOUIS - A St. Louis man who was on parole for murder has been sentenced in connection with a home burglary in south St. Louis. According to the St. Louis Circuit Attorney’s Office, 60-year-old Kenneth Howard was sentenced to 10 years in prison. He was found guilty by a jury of first-degree burglary and [...]

A 21-year-old was arrested Monday in connection with a street takeover in the Bevo neighborhood in which a stolen car was torched on the roadway.

Josh Hawley says he is launching an investigation into OpenAI after a reported breach of Hugging Face, an artificial intelligence model-sharing and dataset platform.

A man faces criminal charges in connection with a crash that killed a mother and two children in Granite City over the weekend.

Have you experienced the beauty the fun and beauty of a river cruise? Haven’t figured out the best time to go? Brentwood Travel is hosting a river cruise show on Tuesday, where you can bring all your questions to them.

Each month on FOX 2, we salute local first responders, military, or veterans with our Proud to Serve award. This month, we shine the spotlight on Elise Kraft who serves her Ferguson, MO community as a fire fighter. Elise was nominated by her father who tells us Elise Kraft was nominated by her father, Kurt [...]

KSNF-KODE - Thomas Ross will get out of jail after a federal judge approves his release. Ross won the August Republican primary race for Missouri's 161st District House seat before being charged with trying to plant cocaine and Adderall on his opponent, Louise Secker. Appearing in an orange jail uniform and handcuffs, today in a [...]

FRANKLIN COUNTY, Mo. - Franklin County commissioners could decide Tuesday whether to move forward with two highly controversial large-scale data center projects. Franklin County commissioners are set to meet Tuesday at East Central College to discuss and potentially vote on the two projects that have been at the center of controversy in the region. Commissioners [...]

The St. Louis Metropolitan Police Department has launched an investigation into alleged threats made by an alderwoman to another elected official.

ST. LOUIS - It’s not the news we want, but it is the reality. Another round of very hot and humid air is settling in over the St. Louis region. Tuesday is expected to be the hottest day, with highs in the upper 90s and heat indices at or above 105 F. That 105+ Heat [...]

A 74-year-old man has been charged with second-degree murder in the death of a woman at a Jennings retirement community.

Kenneth Walker III ran for 173 yards and scored two touchdowns in his Chiefs debut, stealing some of the spotlight from Patrick Mahomes and his surgically repaired left knee, and Kansas City exacted some revenge on the Denver Broncos for stealing their AFC West crown with a 31-10 victory Monday night.

Meteorologists from the National Weather Service teamed up with fire and emergency management officials to conduct a fire weather exercise based on lessons learned from last year’s devastating fire season. 

Quinn Mathews took a no-hitter into the sixth inning and Alec Burleson had an RBI single to lead the St. Louis Cardinals to a 2-1 victory over the San Francisco Giants on Monday night.