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One in 400 African Americans has sickle cell disease in Missouri. Now, the 12th sickle cell treatment center has been opened at BJC.

The Missouri General Assembly sent its first bill to the governor's desk Wednesday afternoon.

The Ballwin man who admits to ripping up a Black Lives Matter and pride poster in a classroom is running for political office and legally changed his name in the past.

By a vote of 15-7, the Madison County Board voted in favor of sending a non-binding referendum to voters in November. County voters will be asked if they want to separate from Cook County to form a new state.

O'FALLON, Mo. - A teen that was reported missing has been located safe late Wednesday evening, according to the St. Charles County Police Department. He was located by two St. Louis Metropolitan Police officers walking in downtown St. Louis around 6 p.m., which was a little over 24 hours after he was last seen. "Praise [...]

Imagine being wanted by police for someone else’s crime—that’s what a St. Louis man was dealing with until calling FOX 2 for help.

The past day, you may have noticed pollen flying around or your car covered with it.

The EPA is testing sites around the West Lake Landfill Superfund in Bridgeton. 

A Fairview Heights, Illinois, man was indicted Wednesday for allegedly committing sexual abuse on the grounds of Gateway Arch National Park.

For the last 13 months, the sounds of construction have been resonating through Powell Hall in the Grand Center Arts District. Renovations at the historic concert venue continue apace, with the goal of reopening in September 2025, ahead of the building’s 100th birthday.

One of the four men involved in a fatal robbery nearly two years ago was sentenced Wednesday.

On April 17, The Washington Post published a 930-word op-ed by Kloss calling for Missouri voters to have the option of restoring abortion rights in the state.

The alleged world's largest bounce house is on tour throughout the country in 2024, and it will be making a weekend pit stop near St. Louis next month.

A St. Louis man appeared in U.S. District Court on Wednesday and admitted to committing a dozen robberies or attempted robberies in the fall of 2021.

The St. Louisan and Ladue Horton Watkins grad hosts "The Magic Prank Show with Justin Willman" on Netflix.

A strong cold front will move across the region on Thursday, bringing with it a chance for scattered showers and a few strong to severe storms.

ST. LOUIS -- Flags are at half staff at Missouri police stations today to honor a police chief who passed away earlier this month. Governor Mike Parson has declared that U.S. and Missouri flags will be flown at half-staff at all government buildings in Lafayette County and police stations across Missouri on Wednesday, April 17, [...]

An Overland teen will stand trial as an adult for a 2023 fatal carjacking in south St. Louis City.

Tree DNA has helped solve a 2019 cold case within Mark Twain National Forest, marking the first instance of tree DNA being used to resolve a case of illegal tree harvesting in MTNF.

A campaign to legalize abortion in Missouri has raised close to $5 million. Missourians for Constitutional Freedom on Tuesday announced a $4.8 million haul from January through March.