FOX 2 📺

Destination USA's Episode 5 hits the road for a lively look at how Route 66 became a pop culture powerhouse, as the Mother Road celebrates 100 years of history.

In Destination USA, Episode 4, “Neon, Motels & Main Street Dreams,” takes viewers back to the golden age of Route 66, when the Mother Road was more than a highway—it was an experience.

Route 66’s centennial takes center stage as The Mother Road turns 100. This episode of Destination USA takes us to St. James, where a once-quiet stretch of highway evolved into a destination of its own a century later.

The story behind one of America’s most iconic highways continues in Destination USA with Episode 2, “How Route 66 Got Its Number,” celebrating the road’s 100th anniversary. Hosted by Patrick Clark, the 30-minute episode explores how the Mother Road earned its legendary identity.

A Jefferson County, Missouri, man appeared in federal court on Wednesday to be sentenced for engaging in sex acts with an underage teen.

It's been an active weather season for the first half of 2026, where Illinois has already broken a 100-year-old record.

The Saint Louis Zoo has been voted the Best Free Attraction in the United States by the USA Today's 10Best Readers' Choice Awards.

One of St. Louis' most beloved landmarks turns 150 years old Wednesday. For a century and a half, Forest Park has been the backdrop for family picnics, bike rides, summer shows and some of the biggest moments in the city's history.

Earlier this month, a St. Louis grand jury indicted a man whose dogs mauled and killed a woman 17 months ago.

The St. Louis Cardinals announced a significant change in organizational leadership on Wednesday that elevates team President Bill DeWitt III to Chief Executive Officer and allows his father, Bill DeWitt Jr., to step back from the role.

WARREN COUNTY, Mo. - A Foristell man was killed in a single-vehicle crash Tuesday afternoon after his vehicle struck a tree in Warren County. According to a crash report from the Missouri State Highway Patrol (MSHP), the crash occurred shortly before 1:30 p.m. on N. Springtown Rd., north of Rocky Lane. It involved a Buick [...]

The suspect allegedly told the manager, “You don’t want to lose your life. Go in there and open the safe.”

The Illinois Attorney General's Office has charged 17 individuals accused of defrauding Medicaid and other state programs, including four with St. Louis-area ties.

Amazon's Prime Day always has deep, rarely seen discounts on Apple products and it's happening now.

The San Antonio Spurs, the NBA's defending Western Conference Champions, selected St. Louis native Tarris Reed Jr. in the first round of the 2026 NBA Draft.

The St. Louis Cardinals are preparing to hold a highly-anticipated press conference Wednesday afternoon on the franchise's future "organizational leadership."

ST. CHARLES COUNTY, Mo. - Crews located the body of a man who jumped into the Missouri River during a pursuit in St. Charles County last week. According to the drowning report from the Missouri State Highway Patrol, officials found the body of the 32-year-old St. Louis man around 2:30 p.m. Tuesday. Prior FOX 2 [...]

Officials located a body in the Mississippi River Tuesday evening.

Prime Day always means big savings on curling irons, blow dryers and more!

CAHOKIA HEIGHTS, Ill. - Cahokia Heights police are increasing patrols during the July 4 holiday. The Cahokia Heights Police Department will join Illinois State Police and 200 other officers to look for drivers violating the law during the holiday. Increased patrols have already begun and are expected to continue until Monday, July 6. Police advise [...]