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When a routine heart surgery took an unexpected turn, one family was suddenly facing the possibility of losing a loved one. But an advanced medical treatment gave him another chance.

The St. Louis Board of Aldermen consider dedicating part of the city's adult-use marijuana tax to Code Blue to help people experiencing homelessness in the winter.

One man died from his injuries after a double-shooting Thursday evening in High Ridge, and a suspect now faces criminal charges, according to the Jefferson County Sheriff's Office.

For the first time in 25 years, the Show Me Showdown returned to St. Louis on Friday night. The Saint Louis University Billikens took on the Missouri Tigers in a basketball game that brought two dedicated fan bases together at the Enterprise Center.

The Ferguson Police Department is asking for the public's help with finding a woman who went missing two months ago.

The new Byway Discovery Center at Great Rivers Park officially opened in Godfrey, Illinois, marking the completion of the first phase of a project aimed at connecting visitors with attractions and outdoor recreation along the Great Rivers National Scenic Byway.

A police investigation is ongoing in Collinsville after a skull was found in a creek bed.

Around 40,000 people are gathering in St. Louis for the Church of God in Christ’s 118th Holy Convocation, an annual gathering that puts the city in the national spotlight.

On Saturday, November 7, 2026, from 8:30 a.m. to 12:30 p.m., the Sixth Annual First Ladies of St. Louis Health Empowerment Seminarwill be held at Greater Grace Church on Pershall Road in Ferguson. The event is free and open to everyone.

St. Louis residents in the Central West End and Dogtown neighborhoods questioned emergency response delays following several high-stress incidents on Halloween night.

Fox 2 investigator Chris Hayes returned to the St. Louis County municipality of Beverly Hills following reports of a potential illegal business tax, after city officials acknowledged they cannot locate the ordinance establishing the tax.

Robbie Avila will not play in Friday night's SLU Billikens matchup against the Mizzou Tigers due to an apparent roster conflict, according to College Sports Commission.

Train horns in St. Louis could stop within the next 7-10 days as the city moves closer to regaining its federal "quiet zone" status, according to the mayor's office.

A teenager was injured in a shooting at a short-term rental party Wednesday in St. Louis' DeBaliviere Place neighborhood, police say.

Ascension Care Management Insurance Holdings is set to eliminate 51 positions and close its St. Louis area facility starting Jan. 8 as part of a plan to outsource operations.

The Republican uncle of pop star Chappell Roan has been tapped as the next majority leader of the Missouri state House, taking on the role as the GOP grapples with its worst election defeat in decades.

A freeze warning is in effect across the St. Louis region tonight as temperatures are forecast to drop into the 20s and low 30s ahead of a chilly weekend.

The St. Louis Cardinals promoted Rob Cerfolio to general manager as part of a major front-office restructuring led by president of baseball operations Chaim Bloom.

A man died following a shooting late Thursday night in the 7300 block of Wallington Walk in north St. Louis County, according to the St. Louis County Police Department.

A 58-year-old Arnold man died Wednesday after a mechanical failure caused him to be ejected from his boat on the Lake of the Ozarks in Morgan County.