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Players have rejected Major League Baseball’s “best and final offer” to end the sport's lockout before the league’s deadline to avoid canceled games.

After leading Illinois through a deadly pandemic, Illinois Department of Public Health (IDPH) Director Dr. Ngozi Ezike is stepping down.

MLB owners had set a new deadline of 4pm Central Tuesday to reach a deal with the Players Association to avoid cancelling regular season games. Players have not agreed to that timeline.

While jurisdictions across the state drop or amend mask mandates or other COVID-19 mitigation efforts, Missourians should remember the pandemic is still happening.

ST. LOUIS-- Teams or sports designed for females, women, or girls would not be open to students born as male under a bill heard in a Missouri State Senate committee Tuesday, bringing the debate over transgender athletics to Missouri. Under Senate Bill 781, called the "Save Women's Sports Act", "No governmental entity, licensing or accrediting [...]

ir County State's Attorney's Office charged a Fairview Heights man for kidnapping his ex-girlfriend at gunpoint and leading police on a high-speed chase.

Paula Nickelson has been with the department for 22 years.

Detectives with the St. Louis County Police Department have identified a man who died in a shootout in Spanish Lake over the weekend.

A home exploded on Millers Court Tuesday afternoon in O'Fallon, Missouri.

They have made it to the St. Louis area and supporters are lining the interstates and overpasses.

The publisher of the St. Louis Post-Dispatch, Buffalo News, Lincoln Journal Star, and dozens of other newspapers rejected Alden's $141 million takeover offer in December.

Christopher Myers' trial on a federal charge of destruction of evidence is scheduled for May 2.

ST. LOUIS (KTVI)--Homicide investigators are trying to find out what led to a man's death on Interstate 70 in North St. Louis Tuesday morning. St. Louis police were called to the area of Westbound I-70 and Goodfellow around 9:30 am Tuesday, where they found a male victim with what may have been a gunshot wound [...]

The state of Missouri's state employee retirement system had roughly $13 million in Russian holdings as of late last week.

The war in Ukraine is especially painful for Ukrainians living in the United States. FOX-2's John Pertzborn shares with us one of those Ukrainians is a part of his family.

Major League Baseball extended its deadline for salvaging opening day and a 162-game season until Tuesday at 5 p.m. after a marathon of 13 bargaining sessions over 16 1/2 hours produced progress toward a deal but left the sides still far apart.

A cold front moves through Wednesday night and it’ll be cooler on Thursday.

Throughout the country, many Ukrainian civilians spent another night huddled in shelters, basements or corridors.

In the wake of his continued controversial comments regarding the Russian invasion of Ukraine, most Republican political candidates in the upcoming Missouri and Illinois primaries still covet an endorsement from former President Donald Trump.

Creve Coeur Mayor Robert Hoffman said the latest announcement from pharmaceutical giant Bayer is welcome news for an area that's ready for new development.