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Five inmates are still on the run after escaping the St. Francois Detention Center on Tuesday night.

Five inmates are on the run after escaping the St. Francois County Jail, and now a manhunt is underway.

The westbound lanes of Interstate 70 reopened to drivers on Wednesday at noon. Those lanes were shut down around 10:45 p.m. Tuesday after officers shot and killed a suspect.

Legal challenges to Illinois' semiautomatic weapons ban began Wednesday with a federal complaint that the 8-day-old law prohibits “commonly possessed” and constitutionally protected guns.

Several people were sent to the hospital on Wednesday after overdosing at the Graham Correction Center in Hillsboro, Illinois.

Former St. Louis Rams head coach Mike Martz and FOX 2 Sports director Martin Kilcoyne are teaming up for a charity event next week.

Major updates to Interstate 70 in Missouri were announced during Gov. Mike Parson's State of the State address on Wednesday.

An 18-year-old from East St. Louis, Illinois, was arrested Wednesday for his alleged involvement in carjacking a uniformed St. Louis Sheriff's deputy last November.

One person was arrested, and another person is wanted for questioning after a shooting Tuesday evening in Mount Vernon, Illinois.

Police are investigating a shooting Wednesday afternoon along an Interstate 70 ramp near Jennings.

A man and woman from southern Illinois were sentenced this week after admitting to identity theft and bank fraud.

A man from Sauget, Illinois, has been charged in connection with a fatal shooting in south St. Louis earlier this month.

There's a bit of uncertainty surrounding one of the largest sources of revenue for the St. Louis Cardinals, and perhaps the chain effect that could follow.

Homicide detectives with the St. Louis Metropolitan Police Department have identified one of three victims who were gunned down during a two-hour span Monday evening.

The program's funding of the extra pandemic benefits from the federal government is scheduled to end after February, and Illinois officials are warning people ahead of time they will need to adjust.

JOPLIN, Mo. — A Netflix program highlighting convicted killers who are sentenced to death features a 1998 Joplin murder in Season 4, titled "The Bogeyman." Last month, the Netflix show "I Am A Killer" focused on episode 5 of its latest season on Gary Black. Black was convicted of killing Jason Johnson, 28, of Joplin. [...]

On January 5, a $50,000 scratcher prize purchased in Charleston, Missouri, was claimed at the St. Louis Regional Office.

Vegas Golden Knights goaltender Robin Lehner and his wife have filed for bankruptcy in Nevada, citing up to $50 million in debts to dozens of creditors.

Hunters harvested nearly 300,000 deer during Missouri's latest deer hunting season, which officially ended last weekend.

Three people are behind bars after police impeded a smash-and-grab theft at one Metro East store.