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Officials with the St. Louis County Department of Public Health are starting to administer a new COVID-19 vaccine booster shot that targets Omicron variants of the virus.

Major League Baseball only recognizes regular season achievements for its all-time leaderboards in terms of career statistics. That means stats such as home runs, hits, victories and more are recognized based on what players did during games outside of postseason.

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CRAWFORD COUNTY, Mo. - A tractor-trailer fire Wednesday has caused eastbound I-44 traffic to be diverted in Crawford County, Missouri. This incident is at mile marker 217 just west of Bourbon, Missouri. Eastbound traffic is being diverted at mile marker 214. The fire started at about 11:30 a.m. MoDOT is asking drivers to avoid the [...]

An elderly man died and a woman was hurt in a head-on crash Tuesday afternoon on Interstate 44, west of the St. Louis region.

Hockey season is the on the horizon. Dozens of prospects with the St. Louis Blues report for preseason practices Wednesday.

A federal judge has sentenced a man prison over a pair of armed robberies that investigators considered to be "violent and aggressive."

Attorneys for the defense and the government presented their closing arguments in a murder-for-hire trial involving a local reality television star accused of plotting to have his nephew murdered for an insurance payout.

An investigation is underway after a man was fatally stabbed late Tuesday night in Festus. The suspect tells police he acted in self-defense.

St. Louis County Executive Sam Page will speak Wednesday morning about more Covid vaccinations in the county.

Adam Wainwright and Yadier Molina. A journey fifteen years in the making leads the St. Louis Cardinals’ legendary tandem to their own unique place in baseball history.  

Workers plan a protest Wednesday morning at the Amazon Fulfillment Center in St. Peters.

"This is meant to be. We’ve got to go celebrate him."

A state Board of Education Commission has been looking into the ongoing teacher shortage being seen across Missouri.

Lawmakers return to Jefferson City Wednesday for a special session on taxes called by Governor Mike Parson.

Sheriff's deputies are looking for the shooter who killed a man in Jefferson County Tuesday night.

An Amber Alert was issued overnight for a 12-year-old Berkeley girl who authorities believe was kidnapped as she left her middle school in Ferguson on Monday afternoon. 

Police are investigating a deadly crash Tuesday that led to Interstate 55 northbound shutting down.

A two-year-old’s mother would not accept that her daughter just tripped and fell. Now, daycare inspectors believe they’ve found the real culprit.

Nearly a quarter of all the state's school districts are only in session four days a week this year due to a shortage of teachers.