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We've finally made it to Opening Day in St. Louis! And we're just hours away from a new St. Louis Cardinals season.

ST. LOUIS - Police are investigating after a man was left dead and another injured following a stabbing in north St. Louis Wednesday night. According to the St. Louis Metropolitan Police Department (SLMPD), the stabbings happened around 8:30 p.m. on the 5100 block of Maple Avenue in north St. Louis' Academy/Sherman Park neighborhood. SLMPD is [...]

Police are investigating after a person was fatally struck by a vehicle at the intersection of South Broadway and Horn Avenue in south St. Louis County, and an ambulance was seen leaving the scene.

ST. LOUIS - Baseball is back! It is going to rain on this Cardinals Opening Day Thursday, but it won’t be raining ALL day. There will be a lot of dry time Thursday, and many festivities (and of course plans at home, work, or school) will be unaffected. But there will be pockets of rain [...]

A local school board faced tough questions Wednesday night about a more than $7 million budget shortfall. 

Thursday will mark the first-ever Opening Day matchup against interleague foes St. Louis Cardinals and Minnesota Twins. It will also feature a head-to-head pitching battle against close friends Sonny Gray and Pablo López.

More people are turning to testosterone replacement therapy. In fact, it’s estimated that prescriptions for the treatment exceeded 11 million in 2024.

ehab Bar and Grill, a longtime St. Louis Pridefest partner, is just one of the local establishments pushing back against Anheuser-Busch's

The verdict came on March 25, which involved a malpractice case that left a child permanently brain-damaged.

The St. Louis Cardinals are gearing up for their home opener, promising fans an exciting experience with new food venues at Ballpark Village and a special exhibit celebrating the fandom.

Crushed Red Pizza, located at the St. Louis Lambert International Airport, was named "Top 100 Movers & Shakers" for its creative pizza kiosk program.

On Wednesday, FOX 2 got a media preview tour of the new features at the Old Courthouse at Gateway Arch National Park in downtown St. Louis.

A 17-year-old boy from Fairview Heights, Illinois, was arrested for first-degree murder in relation to an east St. Louis shooting that happened on March 23.

Mom's Deli has announced it will be relocating to a new location, with plans to reopen soon.

A St. Louis man convicted of using fake checks in a vehicle sale scheme was sentenced Wednesday in Illinois federal court.

Missourians who purchased product from Victoria's Secret online could be paid as part of a class action lawsuit against the lingerie retailer.

Sen. Tammy Duckworth (D-Ill.) called Secretary of Defense Pete Hegseth a “f‑‑‑ing liar” and demanded his resignation, after the top military official repeatedly insisted he did not share classified information and war plans in an unsecured group text message. Duckworth — a combat veteran, former Black Hawk helicopter pilot and member of the Senate Armed [...]

The 2025 St. Louis Cardinals home opener is set for Thursday, March 27 against the Minnesota Twins at Busch Stadium. First pitch is set for 3:15 p.m.

St. Louis Lambert International Airport saw the most passengers it's seen in over two decades last year, according to a new annual report.

One St. Louis university campus was noted as one of the country's most beautiful and was compared to having the charm of a small European town, according to Condé Nast Traveler.