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A man accused in a St. Clair County murder case in October who reportedly fled across state lines to St. Louis is now behind bars.

A St. Louis man died late Friday night after a crash in West Alton, according to the Missouri State Highway Patrol.

Beginning on Jan. 27, 2026, Southwest Airlines is enacting a new assigned seating policy as well as new requirements for plus-size customers.

ST. LOUIS - The Dense Fog Advisory remains in effect until 9AM Saturday morning. Through the afternoon it'll be mostly cloudy but temperatures will once again be mild, in the low to mid 60s. A few showers are possible in our northern counties tonight ahead of a warm front lifting north across the region. A [...]

ELSBERRY, Mo. - A vape shop employee was shot during an armed robbery in Elsberry around 7 p.m. Friday night. The incident occurred at a vape shop located on Broadway. Following the shooting, the employee was treated at the hospital and later released. The Lincoln County Sheriff's Office has released photos of the suspects involved [...]

ST. LOUIS - Local basketball highlights and analysis from Fox 2's Kevin Ryans and Jim Powers.

Police say domestic violence cases may rise during the holiday season. But there are resources available if you, or someone you know, needs to make a safe exit from a dangerous situation.

Homer G. Phillips Hospital opened its doors in St. Louis, Missouri, in 1937. It was the first teaching hospital west of the Mississippi River and the only public hospital in the Gateway City to serve the Black community until 1955, when steps were taken to abolish segregation.

Residents at the Rockwood Springs Apartments in Wildwood awoke on Christmas morning to discover that 18 vehicles had been broken into overnight, raising serious safety concerns.

Missouri and Virginia have a chance to make history in the Gator Bowl.

FOX 2 Sports Director Martin Kilcoyne looks back on the highs and lows of St. Louis sports in 2025.

An abandoned football field near Louisiana Avenue and South Grand Boulevard in Dutchtown has become an unofficial dog park for neighborhood residents.

A Christmas night fire caused heavy damage at Tony's Donuts, forcing the well-known Hazelwood donut shop to close for repairs.

The St. Louis Board of Aldermen opened the application process for hiring an "interim" St. Louis City Sheriff on Friday, a contentious move in the showdown over who ultimately appoints the next sheriff.

One motorcyclist died in a crash Friday afternoon in south St. Louis County, police say.

A Christmas night party at a Cahokia Heights event space turned chaotic early Friday after gunfire erupted inside the crowded venue, injuring one person and prompting a broader police investigation into the location’s operations.

Several hospitals across the St. Louis region have been named among the nation's best in a new Forbes list, earning praise for patient care, value and hospital performance.

President Trump's first year back in office saw a whirlwind of executive actions, the passage of a major reconciliation bill and the rapid remaking of the federal government. Trump campaigned in 2024 on bringing down prices, implementing the largest deportation program in American history and rolling back various initiatives that took hold during the Biden [...]

Willie Chappel, 74, was attacked at his home in April 2025 and died on October 3, 2025, with the Medical Examiner ruling the cause of death a homicide and investigators seeking leads in the case.

ST. LOUIS -- A man was shot and killed late Thursday evening in north St. Louis, police said. Officers found the victim just after 11 p.m. in the 5100 block of Northland Avenue. The man, identified as 26-year-old Malik Holmes, was taken to a hospital, where he later died from his injuries. Homicide detectives are [...]