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It wasn’t an Opening Day sweep against the Tampa Bay Rays, but the Cardinals take two out of three to start the season and leave the weekend encouraged by some promising early performances.

Neurological disorders—such as ALS, MS, and Alzheimer’s disease—have devastated families across our area and the world. But right here in St. Louis, a group is working to change lives through groundbreaking research at Washington University.

A controversial data center proposal in Festus is raising serious legal questions about transparency at city hall, shifting the debate from development to public trust.

A man is recovering at the hospital after being shot multiple times last week during an argument.

Detectives with the St. Louis County Police Department are investigation a fatal shooting Sunday in an unincorporated part of the county.

A Ferguson man is facing charges for breaking into a home to escape a beating.

Yandy Díaz singled four times, doubled and drove in four runs, and Steven Matz notched the victory against his former team as the Tampa Bay Rays beat the St. Louis Cardinals 11-7 on Sunday to avoid a season-opening sweep. Jonathan Aranda added three hits and two RBIs, and Cedric Mullins also drove in two as the top three in the Rays’ lineup combined for nine hits and eight RBIs. Jordan Walker, Nolan Gorman and Pedro Pagés homered for St. Louis.

A Cool Valley woman is in custody for stabbing their sibling last week.

It’s not every weekend that fans in St. Louis get to experience a full slate of professional sports all in one day. But this Saturday, the city was alive as three of its teams — the Battlehawks, Cardinals, and Blues — all played at home, creating an electric atmosphere downtown.

ST. LOUIS COUNTY - A St. Louis County police officer shot a 30-year-old suspect Sunday morning after the man allegedly held a victim at gunpoint during a domestic disturbance in Shrewsbury. The shooting occurred just after 5:30 a.m. in the 7500 block of Murdoch Avenue. Police say the suspect's injuries are not life-threatening. The incident [...]

ST. LOUIS - A 68-year-old man died Saturday afternoon after suffering a cardiac episode following his arrest by St. Louis police. Detectives with the Force Investigations Unit are investigating the in-custody death. The incident began just after 1 p.m. on Saturday when District one officers saw the man riding a bicycle near the intersection of [...]

Freshman Keaton Wagler scored 25 points and Illinois ended Iowa's underdog March Madness run by dominating in the frontcourt, beating the Hawkeyes 71-59 on Saturday to advance to the Final Four for the first time since 2005.

Thousands of demonstrators gathered across the St. Louis region on Saturday as part of the nationwide “No Kings” rallies, a coordinated protest movement expressing concern over executive power, federal policy decisions, and the direction of the country.

The Missouri Department of Conservation is offering a rare glimpse into the winter life of black bears in the state.

Members of the union representing Illinois State University voted overwhelmingly to authorize a strike, and have given the university a 10-day notice of their intent to strike if an agreement is not reached by April 8.

After a Kearney, Missouri family was told their son was taken off the list for a liver transplant, their seven-month-old son has passed away.

In an absolute roller coaster of a game, the St. Louis Cardinals beat the Tampa Bay Rays 6-5 on a walk off single by Wetherholt in the 10th.

Missouri Attorney General Catherine Hanaway said her office has sent 33 cease-and-desist letters to unlicensed retailers accused of selling cannabis products outside of the state's laws, alleging that the businesses are selling deceptively marked and unsafe substances.

The St. Louis Battlehawks opened their 2026 season with a 16-10 win over the DC Defenders in Saturday’s home opener at The Dome at America’s Center.

Edward Jackson, 43, was ordered held pending the outcome of allegations he had large amounts of heroin and methamphetamine at his home, as well as a 9mm pistol, 16 malnourished and injured dogs, and equipment used for dogfighting.