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Supporters of the St. Louis Metropolitan Police Department who want control of the department to stay in the city took their case to Jefferson City, Missouri.

The field is ready for the first pitch and Opening Day at Busch Stadium on Thursday. The St. Louis Cardinals will face an American League team at home to kick off the season.

Prized prospect Jordan Walker is set for his MLB debut Thursday on one of the baseball's biggest stages: Opening Day in St. Louis.

An Alton, Illinois, man faces a minimum 93-year prison sentence after being convicted last week for a 2021 triple shooting.

The ingredients are on the table for a severe weather outbreak across the mid-Mississippi River Valley Friday.

A break in a decades-old Missouri cold case, as Lincoln County authorities announced the successful identification of human remains found in 1984.

The couple received a $100 red light violation in the mail four months ago. The catch is that the car on camera isn't theirs, and they say the camera misread the plate.

The FOX 2 photographer in the helicopter, Doug Larson, says that this is a rare sight to see.

Charging documents say the defendant, who is white, made 15 to 17 calls on Monday and Tuesday threatening a Black judge, who is not named in the affidavit.

St. Louis’ elected prosecutor says she will run for reelection in 2024, even as she tries to fend off an effort by Missouri’s attorney general to force her out of office.

The state's rainy day fund now stands at $1.22 billion.

House gives first-round approval to $45.6 billion budget plan after cutting $2.1 billion from spending proposed by Gov. Mike Parson.

Despite pleas from community members who say the landfill is responsible for mysterious illnesses, federal environmental regulators said Tuesday they can’t provide a timeline for cleanup.

Critics allege the lawsuit is a way to ‘relitigate’ responsibility for millions of acres of damage to crops and natural areas across the Midwest and South.

Officials have estimated 200,000 Missourians could eventually lose coverage as a pandemic policy ends. State Medicaid leaders say they are working to ensure those who are eligible aren’t kicked off.

Most winning ball clubs will have at least one utility player they can plug into any position at any given time that benefits the team. The St. Louis Cardinals made the concept of versatility a priority when constructing their 2023 roster.

The U.S. Food and Drug Administration on Wednesday approved selling the leading version of naloxone without a prescription, setting the overdose-reversing drug on course to become the first opioid treatment drug to be sold over the counter. It’s a move that some advocates have long sought as a way to improve access to a life-saving [...]

An investigation is underway into the death of a six-week-old child in St. Louis.

The Missouri Senate gives first-round approval to a bill that would ban texting while driving. Missouri is one of only two US states without a law that prohibits people over 21 from texting while driving.

A new electric train is rolling down the tracks at the Saint Louis Zoo.