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Scientists may have reached a breakthrough in the fight against Huntington’s disease, a rare and fatal inherited brain disorder with no cure. For the first time, a gene therapy has been shown in clinical trials to significantly slow the progression of the disease, raising cautious optimism among researchers and families.

A St. Ann woman shot overnight by a St. Louis County police officer along Interstate 70 has been charged.

The Sikeston Department of Public Safety is mourning the death of one of its officers who was killed in the line of duty.

The Webster Groves Police Department is investigating multiple reports of jewelry stolen from an apartment complex last week. At least one suspect has been arrested and charged.

A Washington County, Missouri, woman appeared in court Tuesday for a fatal shooting last week at a home she shared with the victim.

A program that provides food assistance to women, infants, and children in Missouri has made changes to its coverage, including substituting store brands for national brands and removing certain items, but the amount of food provided will remain the same.

ST. LOUIS - It's almost time again for St. Louis Blues hockey. The Blues open the 2025-26 season Thursday at home against the Minnesota Wild. It will be Jim Montgomery's first full season as head coach. The Blues are also rocking new jerseys this season that pay tribute to their storied past. On Monday, the [...]

The St. Louis Metropolitan Police Department announced that two individuals are in custody following a fatal shooting in Midtown Monday evening.

The Missouri Attorney General is moving forward with the case to remove St. Louis Sheriff Alfred Montgomery, filing a motion for a partial summary judgment Tuesday in the ongoing court case.

The City Museum in St. Louis has transformed into 'Fright at the Museum' offering Halloween-themed attractions and events now through October 26, including daily shows, skeleton performers, storytelling, two pop-up bars, and a new séance room.

Union employees in the Cahokia Unit School District have been without a new contract for 38 days as negotiations between the union and the district continue to stall, with the union opposing the district's proposal to separate the three employee groups into separate contracts and district leaders arguing that the changes are long overdue and aim to improve student outcomes.

ST. LOUIS COUNTY, Mo. - A woman was hospitalized early Tuesday morning after being shot by a police officer on Interstate 70 in Earth City. According to the St. Louis County Police Department, the incident occurred around 12:30 a.m. on eastbound I-70, near the Blanchette Bridge. The incident started after police received a call for [...]

ST. LOUIS - A cold front is beginning its pass through the region this Tuesday morning. A few light showers will be possible along and behind the front through the afternoon. The front will also work to kick the heavier rain over southern Illinois off to the east. So, widespread beneficial rain isn’t in the [...]

The department pointed to cell phones, smart-watches, laptops and tablets as a few examples of common items containing lithium-ion batteries.

The decision was made after the team's roster dwindled from 38 players to just 20, raising safety risks according to Saint Louis Public Schools.

CHICAGO (AP) — Illinois leaders went to court Monday to stop President Donald Trump from sending National Guard troops to Chicago, escalating a clash between Democratic-led states and the Republican administration during an aggressive immigration enforcement operation in the nation’s third-largest city. The legal challenge came hours after a judge blocked the Guard's deployment in [...]

The Saint Louis University Department of Public Safety shared on social media that there is large police presence in The Village Apartments.

Multiple people have been arrested following a new patrol strategy led by the St. Louis Metropolitan Police Department.

A former gas station clerk has been charged for allegedly stealing a winning lottery ticket at Casey’s General Store in Union, Missouri.

After being sworn in as Missouri’s first woman Attorney General, Catherine Hanaway promised to continue her predecessor’s ongoing legal battle with with St. Louis Sheriff Alfred Montgomery.