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Two children died in a house fire Friday afternoon in Cahokia Heights, officials tell FOX 2.

ST. LOUIS -- February is American Heart Month and Patricia Brothers is spreading awareness about the #1 killer of women: heart disease. Due to her weight, Brothers was diagnosed with Afib, a type of abnormal heartbeat and high blood pressure. She was determined to make a change and lost 200 pounds to save her heart. [...]

Starting this weekend, people in Missouri's 573 area code will need to dial all ten digits of a phone number in order to make a call.

A Missouri Lottery player won the jackpot prize of $89,000 by playing the  Show Me Cash. His ticket matched all five numbers drawn in the Feb. 4.

A man faces felony charges more than half a year after a deadly shootout at a north St. Louis gas station involving several people.

Masyn Winn is gearing up for his first full big-league season after a cup of coffee at the MLB level last year, and he'll likely begin the season as the Cardinals' starting shortstop.

Easter is almost here. To celebrate, Walmart has a collection of egg-cellent décor.

FOX 2 is in your neighborhood, Alton!

A Fayetteville man pleaded guilty and was sentenced to 30 years in prison on Wednesday for his involvement in a 2022 crash that killed a Missouri man, according to court documents.

The Champaign County Coroner has confirmed the cause of death for a University of Illinois student found dead on campus last month.

Baby Olivia isn't a real baby. It's an animated fetus that develops over the course of a three-minute video that has become a new front in state-level abortion politics.

Authorities say a Virginia college student reported missing last week was apparently seen at a Missouri restaurant on Wednesday before he left the restaurant alone and drove away.

James Taylor and his all-star band will perform live at the Hollywood Casino Amphitheatre on Thursday, June 6.

The man charged with hitting Jane Edmondson last year is due in court Friday.

As Punxsutawney Phil predicted there would be an early spring this year, it gives the advantage of taking some hikes in the warmer weather earlier. The areas around St. Louis have some hidden gems where hikers can go to see a scenic waterfall.

One of Missouri's largest cannabis companies is opening its first dispensary in St. Louis.

Financial advisory firm, Deloitte, says the automotive industry is expected to see a surge in demand for workers skilled in electric vehicle technology and cybersecurity this year.

The Missouri Libertarian Party is holding its 2024 convention this weekend.

Missouri officials are worried new federal welfare rules could cost the state 90-million dollars in funding for programs affecting low-income people.

A St. Louis man who pleaded guilty to killing four people in a crash last February is facing years behind bars.