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Authorities are searching for five people accused in a Fenton gun store burglary earlier this week.

Professional football is almost back in St. Louis as the Battlehawks prepare for the XFL's revamp in 2023.

A St. Louis man will spend upwards of four decades behind bars after being sentenced for the 2021 murder of an actress outside her south city home.

Starting next month, anyone 21 or older can legally purchase recreational marijuana in Missouri.

On Wednesday, more than two dozen dogs will arrive at the Humane Society of Missouri's Best Buddy Center in Maryland Heights for a veterinary exam after being rescued earlier in the day.

ST. LOUIS, Mo. -- The Drew Barrymore Show featured a 13-year-old from St. Louis Wednesday in a segment called, "Drew's Helpers." Legacy Jackson helps organize local service projects to help others. "I am so inspired by you, I can't even handle it," said Drew Barrymore. Legacy was already doing charitable work for others and noticed [...]

The conference comes two days after Buffalo Bills safety Damar Hamlin collapsed during the first quarter of the Buffalo Bills vs Cincinnati Bengels game.

Missouri lawmakers on Wednesday returned to work for a session that Republican leader have said will focus on making it harder to amend Missouri's Constitution.

Scientists are hoping to improve the effectiveness of current flu vaccines.

A deadly fire that broke out at a Spanish Lake apartment complex on New Year's Eve has been deemed accidental.

A Franklin County woman was sentenced Wednesday to two additional years in federal prison for committing pandemic loan fraud after previously pleading guilty in a six-figure embezzlement case.

The Quadrantid shower originates from an asteroid rather than a comet – the 2003 EHI asteroid, which takes 5.52 years to orbit the sun, according NASA.

An investigation is underway as several police officers have responded to a situation outside a Dobbs center in Maryland Heights.

While about 100 players experienced Damar Hamlin’s cardiac arrest in person, hundreds more are also feeling the effects.

The Rizzuto Show is parting ways with radio personality Tony Patrico.

According to the annual U-Haul Growth Index, St. Louis, Raleigh-Durham, N.C., and Nashville, Tenn., are among the more notable growth markets to make the top 25.

The St. Louis Circuit Attorney's Office has dropped charges against a woman accused of threatening and attempting to rob a St. Louis alderman last month.

ORCHARD PARK, N.Y. (AP) — Damar Hamlin’s recovery is moving in “a positive direction” two days after the Buffalo Bills safety collapsed and went into cardiac arrest during a game against Cincinnati, the player’s marketing representative said Wednesday. “We all remain optimistic,” Jordon Rooney, a family spokesman who described himself as a good friend of [...]

Top priorities in the legislative session that begins Wednesday will be making it harder to amend Missouri’s Constitution, sports betting, and education issues ranging from attending out-of-district schools to how children are educated about racism.

A teenage boy is in critical condition after a St. Louis shooting Wednesday morning.