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Companies, families and friends lace up their shoes to get some good exercise, all while promoting heart disease awareness.

Some severe thunderstorms, gusty winds and small hail chances are likely Saturday from the afternoon to early evening hours in the St. Louis region.

A gunman shot a driver and a passenger on Interstate 70 overnight in St. Louis. One woman shot suffered critical injuries.

Don Denkinger, a major league umpire for three decades whose blown call in the 1985 World Series overshadowed a career of excellence, died Friday. He was 86.

From the first coffee houses in the Ottoman Empire to Boston's London Coffee House, cafes have always been an egalitarian place to gather, sip, and share ideas, many of which have changed the world. During the Enlightenment, cafes would regularly entertain the likes of Voltaire, Rousseau, Benjamin Franklin, Thomas Jefferson, and Isaac Newton. Later, Simone [...]

This morning, cars are moving again in both directions on I-64 near Hampton after a massive water main break.

Thousands of people are expected to participate in the St. Louis Heart Walk this morning.

This morning, the weather started off mild and humid.

For decades, the organization has assisted refugees in making St. Louis their new home. Today's drive supports refugees from Afghanistan, Haiti, the Congo, Cuba, Syria, and others.

The St. Louis Dental Center is helping to make oral healthcare available to everyone in need regardless of economic, cultural, or linguistic backgrounds by training international dentists and breaking language barriers.

Fairview Heights homeowners say sinkholes are popping up in their neighborhood, and it’s a problem that’s been getting worse for years.

Crimes caught on camera led to a drug dealer going to federal prison for 35 years. It’s an eye-opening case that shows how drug overdoses impact more than just the users.

FOX 2 first reported the aftermath and the toppled radio tower at the Shrine of Our Lady of the Snows in Belleville, Illinois, on April 18.

Some St. Louis residents say they are ready to move to another area. They have grown weary of hearing gunfire and seeing the suffering that violence leaves behind.

Chaos in Missouri's Republican-led Senate on the final day of session Friday meant the failure of a longtime GOP priority to make it harder to amend the state's constitution, which lawmakers predicted could ease the path to restoring abortion rights in the state.

We love movies. They offer us special little glimpses into worlds that many of us could only fathom to dream of in our minds. Only through the magic of cameras, CGI, and stellar casts and crews are we able to see them played out at a moment's notice. Movies have become more than chances for [...]

Two organizations in the St. Louis region have joined forces with the goal to lower homicide rates.

Fire crews rescued at least three people from an SUV stranded on Interstate 64 amid massive flooding from a water main break Friday afternoon.

A mother safely delivered her baby boy in the car thanks to a Pike County 911 dispatcher.

A stretch of Interstate 64 is flooded in St. Louis after a water main break Friday afternoon. The interstate is flooded in both directions of Interstate 64 near Tamm Avenue.