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Sheriff's deputies are looking for the shooter who killed a man in Jefferson County Tuesday night.

An Amber Alert was issued overnight for a 12-year-old Berkeley girl who authorities believe was kidnapped as she left her middle school in Ferguson on Monday afternoon. 

Police are investigating a deadly crash Tuesday that led to Interstate 55 northbound shutting down.

A two-year-old’s mother would not accept that her daughter just tripped and fell. Now, daycare inspectors believe they’ve found the real culprit.

Nearly a quarter of all the state's school districts are only in session four days a week this year due to a shortage of teachers. 

An exciting development is underway in downtown Clayton. The construction has started on the city's first ground up hotel development in 20 years - the AC Hotel Clayton.

Six turtles are rescued from a Chesterfield park after being thrown out in a nearby trash can.

The St. Louis Cardinals hosted the Milwaukee Brewers at Busch Stadium Tuesday night.  Some fans traveled a long way to see the two teams play. 

The St. Louis County Medical Examiner's Office has been facing issues with storage. They do not have enough space to store bodies.

In a poll conducted on which local natural landmarks people would most like to visit, Belleview's Elephant rocks ranked third place.

Major League Soccer's newest team, St. Louis City SC, now has a team store open for business.

The Missouri Supreme Court on Tuesday refused to take up a lawsuit challenging a ballot proposal to legalize recreational marijuana use in the state.

Amtrak is cancelling seven long-distance trips starting on Wednesday amid the looming possibility of a railroad labor union strike.

Governor Mike Parson participated in a groundbreaking ceremony surrounding American Foods Group, LLC's (AFG) new state-of-the-art beef processing facility in Warren County Monday, September, 13.

The St. Louis County Police Department mourns the loss of one of its longtime officers.

A 21-year-old sailor was laid to rest Tuesday following a decades-long effort to identify remains pulled from Pearl Harbor, more than 80 years after he was killed in the attack that propelled the United States into World War II.

The jobs include sign-on bonuses and great benefits packages.

A woman won $50,000 through a Powerball drawing after she purchased a Quick Pick ticket in St. Peters.

SPRINGFIELD, Ill. (WMBD) -- With the general election two months away, both Democrats and Republicans are in attack mode. Republicans in particular are using certain legislature--House BIll 3653, or the SAFE-T Act--to motivate voters. But there are many claims floating around about what the bill actually does or does not do. WMBD's digital producer Maggie [...]

Sports Classics owner Dick Zitzmann tells FOX 2 that Pujols' 697th home run ball could go for hundreds of thousands of dollars at auction.