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With travel on the rise again, a St. Charles County clinic is offering yellow fever vaccination for people going abroad for vacation or humanitarian work.

Just last year, Albert Pujols embarked on his final run as a St. Louis Cardinals and reached 700 home runs. He's now enjoying retirement after 23 storied seasons in Major League Baseball.

A former inspector with the Missouri State Highway Patrol admitted Tuesday in federal court to accepting thousands of dollars in cash bribes over false vehicle certifications.

The St. Louis Cardinals are selling tickets to their upcoming home series against the Los Angeles Angels for as low as $7. The Angels pay a visit from Tuesday, May 2 to Thursday, May 4.

A relatively-rare St. Louis Blues playoff miss has many committed fans finding another hockey team (or a player) to cheer on during the big dance this year. That's true even for the most devoted of Blues fans, like Jon Hamm.

A Cole County judge on Friday rejected a challenge to a 2021 law used by Missouri’s attorney general to sue school districts over COVID-19 mask policies.

The Missouri Department of Revenue is closing the license office in Downtown St. Louis next month.

The Daviess County Sheriff's Office and Missouri State Highway Patrol are investigating after a mushroom hunter found human remains.

Food that's good for your soul doesn't come just anywhere. That said, St. Louis is home to a restaurant recently acclaimed for having the best soul food in Missouri.

In a surprising move Monday, the Missouri House failed to pass a bill that would have reinstated the presidential primary for the 2024 election.

Illinois Lottery officials say this is the biggest prize in nearly three years.

Rapper LL Cool J is set to headline The F.O.R.C.E. (Frequencies of Real Creative Energy) tour that kicks off this summer. The Enterprise Center will be hosting one of the 24 shows Saturday, August 19. Tickets go on sale Friday, April 28, at 10:00 a.m.

The state of Missouri will begin accepting applications from certain small businesses interested in selling cannabis earlier than expected.

Gas prices are showing signs they may have plateaued this week. The cooling off in retail gas prices comes as the price of oil has fallen several dollars compared to this same time last week.

One of baseball's biggest stars comes to St. Louis next week. Shohei Ohtani and the Los Angeles Angels pay a visit to Busch Stadium for a three-game series from May 2-4.

A Michigan man faces DWI charges in a crash that injured three St. Louis-area law enforcement officers over the weekend.

WASHINGTON (AP) — President Joe Biden on Tuesday formally announced that he is running for reelection in 2024, asking voters to give him more time to “finish this job” and extend the run of America’s oldest president for another four years. Biden, who would be 86 at the end of a second term, is betting [...]

A St. Louis man died Sunday morning after a collision involving a train in Warren County, according to the Missouri State Highway Patrol.

Colonel William 'Bill”' Miller has spent his career serving the country. 

One man was shot and killed overnight in north St. Louis.