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The St. Louis Metropolitan Police Department announced a list of streets and highway ramps that will be closed off for Mardi Gras tomorrow and up until Sunday, March 2.

Skype, a widely used video communication app for many, will be shutting down its service in May, its owner, Microsoft, announced today.

A former De Soto special needs teacher is charged for her treatment of a non-verbal student with autism.  

FOX 2 has learned that hundreds of library Chromebooks are way past their due dates—leaving some with no hope of ever checking one out.

Local businesses are gearing up for one of the biggest weekends of the year—from bars to restaurants and shops. 

Friday marked the last day for 70 workers at Homer G. Phillips Memorial Hospital in north St. Louis.

The warm temperatures have many wanting to go full steam ahead into the spring season. 

There are new gates at the Forest Park-DeBaliviere Metrolink Station, which is part of its Secure Platform Plan.

Lawmakers in Missouri are considering legalizing psychedelic drugs for struggling veterans, according to a new house bill.

ROME (AP) — Pope Francis suffered an isolated coughing fit on Friday that resulted in him inhaling vomit and requiring non-invasive mechanical ventilation, the Vatican said in relaying an alarming setback in his two-week long battle against double pneumonia. The 88-year-old pope remained conscious and alert at all times and cooperated with the maneuvers to [...]

Backstage has compiled a list of movies and TV shows casting roles in Missouri, neighboring states, and nationwide, offering opportunities for aspiring and working actors to submit their applications.

Ozzie Smith, sports icon and Wish Home ambassador, is in Troy, Illinois, with baseball fans, showcasing a new open house that is valued at $500,000; individuals can enter in the raffle to win the home for only $100.

The Saint Louis Zoo has closed two exhibits "until further notice" as a precaution after a wild wood duck found dead on zoo grounds last week tested positive for avian influenza.

The Transworld Halloween and Attractions Show, held at America's Center in St. Louis, is the largest trade show of its kind, featuring over 400 vendors and buyers from 70 different countries, showcasing the latest technology and products for haunted houses, pumpkin patches, and other events.

A man was awarded $1.5 million nearly three years after a tree branch struck him while waiting at a St. Louis bus stop.

ST. LOUIS – Cary Williams is a local marine veteran kickstarting his own tequila business, Aquila Tequila. Aquila Tequila will be a featured drink at The Rhythm and Brews benefit in St. Charles, Missouri, supporting kids of fallen veterans. Williams shares the unique story behind how his business got started and where to find his [...]

The 46th Mardi Gras weekend kicks off in St. Louis with the Mayor's Ball, followed by the Bud Light Grand Parade, and concludes with outdoor sales and events in the Soulard neighborhood.

ST. LOUIS — FOX 2 is partnering with the American Red Cross for a three-day blood drive to promote the need for blood and the new medical drama series, “DOC.” Right now, someone needs blood every two seconds in the U.S., and with recent winter weather thousands of blood and platelet donations went uncollected since [...]

Investigators say a teenager's shooting death in Cahokia Heights was connected with three individual shootouts over one hour.

FOX 2 is partnering with the American Red Cross for a three-day blood drive to promote the need for blood and the new medical drama series, "DOC."