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Crews were responding to an early morning house fire in Cahokia Heights, Illinois.

An overnight fire starts at a vacant home in East St. Louis, but then it spreads to an occupied home, forcing two women, including one in a wheelchair, to get out of the house.

A legal challenge to Missouri's voter ID law is in court Friday in Jefferson City.

A woman was shot in the foot overnight in the Patch neighborhood of South St. Louis.

The Major Case Squad of Greater St. Louis arrested a suspect in a homicide in Clayton.

A St. Louis City police officer was taken to the hospital after he was involved in a crash overnight downtown while responding to a shooting call.

Fontbonne University students and faculty are raising concerns about the possibility of cuts being made to the school's fine arts program.

Thousands in North and South America will participate in the global initiative called "Sleep Out" on Thursday. In St. Louis, Covenant House Missouri is hosting an annual Sleep Out event in support of homeless youth.

Authorities have issued a warrant for a suspect wanted in connection with a man's shooting death Monday morning in Clayton.

The Interstate 55 Corridor Upgrades project will add a northbound and southbound lane in Jefferson County from Festus to Pevely.

Shonte Mueller was joined by family and supporters as she arrived at the East St. Louis City Hall Thursday night for a personnel hearing.  

Some stolen car victims say they’re paying twice for someone else’s crime. Only FOX 2 reported a recent case of a Ballwin woman’s stolen car, recovered, then accidentally sold by the St. Louis tow lot.

The state is making a historic investment into a maternal mortality prevention plan after Missouri has one of the highest rates of pregnancy-related deaths in the country.

It is back to business for General Motors workers in Wentzville. Despite the United Auto Workers union voting down a contract locally, it was approved nationally, superseding the Wentzville vote.

Religious leaders appeared in court Thursday in Downtown St. Louis to fight against Missouri's abortion ban. The case could have major implications for the future of Missouri’s law, which bans most abortions.

We're one week away from Thanksgiving, but it's almost time for families to start picking out their perfect Christmas trees.

While it may not feel too much like ice skating weather yet, winter is right around the corner, and Steinberg Skating Rink at Forest Park is set to open this weekend.

Four St. Louis men face felony charges in connection with a vehicle sale scheme through which they allegedly used fake cashier’s checks to buy vehicles from private sellers online and resold the vehicles for profit.

Buc-ee's, which is set to open its first Missouri location next month, might not stop at one travel center, exploring Kansas City and St. Louis.

CHICAGO — Thirty-eight people were injured and at least 23 were taken to local hospitals after a CTA train crash on the North Side Thursday, the Chicago Fire Department said. According to police, a yellow line train was travelling south near the 7500 block of North Paulina Street when it collided with rail-mounted maintenance equipment [...]