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Get your basketball brackets ready! The first round of March Madness games begin Thursday, which includes an early matchup for the Illinois Fighting Illini.

St. Louis Mayor Tishaura Jones will take part in a health department program Thursday to discuss maternal and child health.

An early-morning house fire resulted in significant damage to a vacant home in East St. Louis.

St. Louis Mayor Tishaura Jones wants to turn the former Workhouse jail site into one that offers tiny homes for struggling residents.

Cool winds are keeping temperatures in the normal range for the next few days, though Thursday might feel a little more cool compared to others around it.

U.S. Interior Secretary Deb Haaland visits St. Louis on Thursday.

St. Louis firefighters were busy overnight with a fire at a vacant house.

An investigation is underway after one person was shot overnight in the Metro East.

ST. CHARLES (KTVI) - More soccer in St. Louis? No problem. St. Charles FC offers athletes and fans top-quality soccer ranging from youth play (ages 5-18) all the way up to the professional ranks of the United Soccer League (USL) 2 and the USL women's league. This year, the program will enter its second season [...]

ROXANA, Ill. - Police in southern Illinois are investigating after a family woke up Wednesday to find their barn on fire and thousands of dollars in equipment stolen. The Roxana fire chief said it's still to early to tell how the fire started. Both police and fire marshals are investigating the incident.

Big news for St. Louis air travelers Thursday, coming more than a thousand miles away in New Haven, Connecticut. Avelo Airlines is announcing exclusive, nonstop service between St. Louis Lambert International Airport and Tweed-New Haven Airport.

ST. LOUIS - A two-year-old was injured after accidentally shooting himself, according to a St. Louis City Sheriff's spokesperson. The incident occurred over the weekend. An off-duty sheriff's deputy left an unsecured firearm in a house. His two-year-old nephew got a hold of the gun and shot himself. According to officials, the child was in [...]

The community gathered at Incarnate Word Academy to hold a prayer service for basketball coach Dan Rolfes in hopes he makes a full recovery.

Millions of people have watched a horrific after-school fight in Hazelwood online, which has revived an old but relevant conversation about safety.

Visitors may be noticing a smaller selection of rental cars available. A combination of spring break travelers and the hail storm last week have dwindled the number of cars to choose from.

The Missouri General Assembly hopes to combat sex and human trafficking while safeguarding the rights of children with legislation moving forward inside the statehouse.

One university in the "Show Me State" receives high marks on a global scale.

The Bradford pear trees are incredibly invasive and non-native species that have spread rapidly across the region.

Detectives are investigating a home invasion that sent a man to the hospital in Pontoon Beach Wednesday. Police are searching for the individual who shot the victim in his home.

The Major Case Squad of Greater St. Louis has been activated to investigate the fatal shooting of a teenager in Pagedale.