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While some doctors say self-medicating trans health care is dangerous, a growing population say they see no other option.

The St. Louis-based organization is being accused of defamation in Colorado in a lawsuit that includes the former president’s campaign and myriad right-wing media figures.

DAVENPORT, Iowa (AP) — People living along the Mississippi River watched warily Sunday as water levels rose in southeast Iowa and northwest Illinois, awaiting spring crests as floodwaters began to slowly recede and reveal damage in areas further north. The National Weather Service said many of the crests across the region this season will rank [...]

The family of a Pike County, Missouri, man who went missing nearly four years ago received word that his remains had been discovered and identified.

They'd gotten into an argument. Both had guns.

The incident happened in an apartment in the 5300 block of Gladstone Place.

The St. Louis County Prosecuting Attorney's Office has charged a 69-year-old man in connection with Saturday's fatal shooting aboard a MetroLink train.

The fire happened on Friday afternoon around 1 p.m. Their home and two vehicles are completely destroyed.

In U2's 2004 song "Sometimes You Can't Make it on Your Own," which is about Bono's late father, he sings, "You're the reason the opera is in me."  At his…

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Homicide detectives with the St. Louis County Police Department's Crimes Against Person's unit are investigating a possible murder-suicide Sunday morning.

Frank Browers, 77, used to work as a logger.

Three teenagers and a young woman were killed late Saturday night in a head-on collision on Highway 79 in Lincoln County.