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Two 16-year-old girls, a 15-year-old girl and a 23-year-old woman died in the crash.

April 30 is National Adopt a Shelter Pet Day. According to the ASPCA, more than 6 million animals enter shelters in the U.S. every year, and there are hundreds of pets across the St. Louis area in need of a forever home.

Less than a week after spotlighting a mother of four’s problems at a rent-subsidized apartment in north St. Louis, the property owner has finally relented.

People from across the St. Louis region are sharing their memories of beloved Cardinals player and commentator Mike Shannon, and the legacy he leaves behind.

CLEVELAND, Texas (AP) — A widening manhunt for a Texas gunman who fatally shot five neighbors continued coming up empty Sunday as officers knocked on doors, the governor put up $50,000 in reward money and the FBI appeared no closer to catching the killer after nearly two days of searching with a team that has [...]

While some doctors say self-medicating trans health care is dangerous, a growing population say they see no other option.

The St. Louis-based organization is being accused of defamation in Colorado in a lawsuit that includes the former president’s campaign and myriad right-wing media figures.

DAVENPORT, Iowa (AP) — People living along the Mississippi River watched warily Sunday as water levels rose in southeast Iowa and northwest Illinois, awaiting spring crests as floodwaters began to slowly recede and reveal damage in areas further north. The National Weather Service said many of the crests across the region this season will rank [...]

The family of a Pike County, Missouri, man who went missing nearly four years ago received word that his remains had been discovered and identified.

They'd gotten into an argument. Both had guns.